Abstract With the increasing number of climate-related events and the growing public awareness of climate change and its potential consequences, new challenges emerge including for high-risk industries and the way to manage their safety. Ignoring the interrelations between the two societal stakes that are climate change and safety might lead to critical situations. This chapter identifies the questions raised by addressing the interplay between safety and climate change at both conceptual and practical levels. It also suggests perspectives for safety science and scientists to have a more significant contribution in this unprecedented context.