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Dernières publications
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Dylan Moutachi, Janek Hyzewicz, Pauline Roy, Mégane Lemaitre, Damien Bachasson, et al.. Treadmill running and mechanical overloading improved the strength of the plantaris muscle in the dystrophin‐desmin double knockout (DKO) mouse. The Journal of Physiology, In press, ⟨10.1113/JP286425⟩. ⟨hal-04643936⟩
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Antonio Atalaia, Dagmar Wandrei, Nawel Lalout, Rachel Thompson, Adrian Tassoni, et al.. EURO-NMD registry: federated FAIR infrastructure, innovative technologies and concepts of a patient-centred registry for rare neuromuscular disorders. Orphanet Journal of Rare Diseases, 2024, 19 (1), pp.66. ⟨10.1186/s13023-024-03059-3⟩. ⟨hal-04460667⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
144
Publications avec texte intégral
Open Access
53 %
Mots clés
CRISPRi
Gene therapy
Dystrophie Myotonique
GABA
KNOCKOUT MICE
DM1
CTG repeats
Motoneuron
Thérapie génique
Male
CTG repeat instability
Transcriptomics
Alternative splicing
Exercise
Animals
Cardiac muscle
Mouse model
BIOLOGIE MOLECULAIRE
Diaphragm
Myotonic dystrophy
Brain
Myotonic Dystrophy Type 1
Therapy
PacBio
Acute coronary syndrome
Muscular dystrophy
RNA interference
Expression
Myostatin
Glutamate
RNA biology
Cell penetrating peptide
Neuron
Antisense oligonucleotides
Gene Therapy
Genotype phenotype correlation
Astrocytes
Humans
Glucocorticoids
Trinucleotide Repeat Expansion
Centronuclear myopathy
Myotonic Dystrophy type 1
Acetylcholinesterase deficiency
Cell culture model
Long read sequencing
Glucocorticoid-receptor
AAV
ARN
Intermediate filament
Cell model
Transgenic mouse model
Dystrophie myotonique
Myotonic Dystrophy
Oligodendrocyte
Endurance training
Mice
Dystrophin
Skeletal muscle
Maximal force
Fibrosis
Exercice
Muscle
CTG repeat contractions
Mouse models
ACETYLCHOLINESTERASE
DMPK
Heart
Duchenne muscular dystrophy
RNA splicing
Cells
Antisense oligonucleotide
Myelin
Central nervous system
Hypoxia
Aging
Heart failure
Gene editing
GSK3
CRISPR/Cas9
Trinucleotide repeat expansion
Transgenic mouse
DMSXL mice
MBNL
Acetylcholinesterase knockout mouse
CMS
Dynamin 2
Astrocyte
Myotonic dystrophy type 1
Brain dysfunction
Cultured
Desmin
Oligodendrocytes
CONGENITAL MYATHENIC SYNDROME
Cytoskeleton
Quantitative microdialysis
Dilated cardiomyopathy
Myotonic dystrophy mouse models
PCR
Glial cells
Autophagy