Most models for predicting the acoustic response of perforated panels are based on the assumption that there are no interactions between the holes. This paper investigates the Holes Interaction Effect (HIE) and distribution effect on the sound absorption coefficient of microperforated panels when submitted to medium and high sound pressure levels (from 90 dB to 150 dB). It is experimentally demonstrated that though the HIE is mostly an added mass effect, the nonlinear resistance parameters depend on the separation distance between the holes. Analysis of the data shows that even with HIE, the nonlinear reactance dependency with velocity is very slight compared to the resistance-velocity-dependency. Microperforated panels of 2 mm thickness with varying pitches between holes were made and tested. Some classical models (based on Fok's functions) demonstrating holes interaction effects are compared to the experimental results performed with an impedance tube. The results can be used for designing optimal perforated panels for duct silencers or for the automotive industry for instance.