Article Dans Une Revue Journal of Parkinson's disease Année : 2024

Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia

Résumé

Alterations of serotonin type 4 receptor levels are linked to mood disorders and cognitive deficits in several conditions. However, few studies have investigated 5-HT4R alterations in movement disorders. We wondered whether striatal 5-HT4R expression is altered in experimental parkinsonism. We used a brain bank tissue from a rat and a macaque model of Parkinson’s disease (PD). We then investigated its in vivo PET imaging regulation in a cohort of macaques. Dopaminergic depletion increases striatal 5-HT4R in the two models, further augmented after dyskinesia-inducing L-Dopa. Pending confirmation in PD patients, the 5-HT4R might offer a therapeutic target for dampening PD’s symptoms.
Fichier principal
Vignette du fichier
jpd_2024_14-2_jpd-14-2-jpd230331_jpd-14-jpd230331.pdf (10.64 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
licence

Dates et versions

hal-04802942 , version 1 (27-01-2025)

Licence

Identifiants

Citer

Rossella Cirillo, Sandra Duperrier, Pathik Parekh, Mathilde Millot, Qin Li, et al.. Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia. Journal of Parkinson's disease, 2024, 14 (2), pp.261-267. ⟨10.3233/JPD-230331⟩. ⟨hal-04802942⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

More